Description

n-Desmethyl 4-Hydroxy Toremifene is a key pharmaceutical intermediate and metabolite of the selective estrogen receptor modulator (SERM) Toremifene. This compound is of significant importance in pharmaceutical research and development, particularly for the study of drug metabolism, pharmacokinetics, and the synthesis of related therapeutic agents. It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in oncology research and the development of hormone-based therapies.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and development of Toremifene and its analogs.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in bioanalytical studies for drug metabolism and pharmacokinetic (DMPK) profiling.
• Research & Development: Serves as a vital tool in preclinical and clinical research for breast cancer and other hormone-dependent conditions.
• Quality Control: Employed as an impurity standard in the analytical testing and quality assurance of Toremifene Active Pharmaceutical Ingredients (APIs).
• Biochemical Studies: Utilized in vitro and in vivo studies to investigate estrogen receptor binding and modulation mechanisms.

Basic Information

Product Name	n-Desmethyl 4-Hydroxy Toremifene
CAS No.	125618-41-9
Molecular Formula	C25H27NO2
Molecular Weight	373.49 g/mol
Synonyms	4-Hydroxytoremifene; FC-1271a; Z-4-Hydroxy N-desmethyltoremifene; (Z)-4-Hydroxy-N-desmethyltoremifene; 2-{4-[(Z)-4-Chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}-N-methylethanamine; N-Desmethyl-4-hydroxytoremifene; 4-Hydroxy N-desmethyl Toremifene
EINECS	Contact for details

Quality Control

Our n-Desmethyl 4-Hydroxy Toremifene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade standards suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.