Description

4-Hydroxy-3-(Trifluoromethyl)Benzonitrile is a versatile fluorinated aromatic intermediate of significant interest in advanced chemical synthesis. Its unique structure, featuring both a hydroxyl group and a trifluoromethyl substituent on a benzonitrile core, makes it a valuable building block for creating molecules with enhanced properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors. It serves as a critical precursor for the development of novel active ingredients, where the introduction of fluorine atoms can dramatically improve metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of new drug candidates, particularly in oncology, CNS, and anti-infective therapies.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystals used in high-performance displays (LCDs).
• Polymer Modification: Incorporated as a monomer or additive to impart special properties like chemical resistance, thermal stability, or specific optical characteristics to polymers.
• Organic Synthesis & Catalysis: A valuable reagent in cross-coupling reactions and as a ligand precursor in organometallic catalysis.
• Advanced Material Research: Investigated for use in organic semiconductors, OLEDs, and other electronic materials due to its electron-withdrawing capabilities.

Basic Information

Product Name	4-Hydroxy-3-(Trifluoromethyl)Benzonitrile
CAS No.	124811-71-8
Molecular Formula	C8H4F3NO
Molecular Weight	187.12 g/mol
Synonyms	3-(Trifluoromethyl)-4-hydroxybenzonitrile; 4-Cyano-2-(trifluoromethyl)phenol; 2-Hydroxy-5-(trifluoromethyl)benzonitrile; 5-(Trifluoromethyl)-2-hydroxybenzonitrile; 4-Hydroxy-3-trifluoromethylbenzonitrile; Phenol, 4-cyano-2-(trifluoromethyl)-; Benzonitrile, 4-hydroxy-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-3-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases. Due to its light-sensitive nature, containers should be amber or opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.