Description

Mitomycin Phosphate CAS NO 124580-38-7 is a chemically modified derivative of the potent antineoplastic antibiotic mitomycin C. This compound is of significant interest in pharmaceutical research and development due to its potential as a prodrug, designed to improve solubility and targeted delivery for enhanced therapeutic efficacy. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel oncology treatments and advanced drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of novel chemotherapeutic agents.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of action, cytotoxicity, and tumor targeting strategies.
• Prodrug Development: A model compound for designing and evaluating phosphate-based prodrugs aimed at improving the pharmacokinetic profile of parent drugs.
• Bioconjugation Studies: Employed in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapies for cancer.
• Analytical Reference Standard: Functions as a high-purity standard for quality control and analytical method development in pharmaceutical laboratories.

Basic Information

Product Name	Mitomycin Phosphate
CAS No.	124580-38-7
Molecular Formula	C15H18N3O6P
Molecular Weight	367.30 g/mol
Synonyms	Mitomycin C Phosphate; 7-Amino-9α-methoxymitosane Phosphate Derivative; Mitomycin Phosphate Ester; (1aS,8S,8aR,8bS)-6-Amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2',3':3,4]pyrrolo[1,2-a]indole-8-yl Dihydrogen Phosphate; Mitomycin Prodrug; Antibiotic MA 759 Phosphate
EINECS	Contact for details

Quality Control

Our Mitomycin Phosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term stability, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.