Description

4-Bromo-2,6-Difluorobenzonitrile is a high-purity halogenated aromatic nitrile building block essential for advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for introducing bromo and difluoro substitution patterns.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the difluorobenzonitrile moiety is critical for bioactivity.
• Ligand and Catalyst Development: Serves as a building block for creating novel ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine atom.
• Fluorine Chemistry Studies: A valuable compound for research into the effects of fluorine substitution on aromatic systems.

Basic Information

Product Name	4-Bromo-2,6-Difluorobenzonitrile
CAS No.	123843-67-4
Molecular Formula	C7H2BrF2N
Molecular Weight	218.00 g/mol
Synonyms	2,6-Difluoro-4-bromobenzonitrile; Benzonitrile, 4-bromo-2,6-difluoro-; 4-Bromo-2,6-difluorobenzene carbonitrile; 4-Bromo-2,6-difluorophenyl cyanide
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,6-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.