Description

2-Fluoro-1-Nitro-4-(Trifluoromethoxy)Benzene is a high-purity fluorinated aromatic building block essential for advanced chemical synthesis. This compound matters because it provides a unique combination of electron-withdrawing groups—nitro and trifluoromethoxy—on a fluorinated benzene ring, enabling precise molecular design. It is primarily needed by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for developing novel active ingredients, particularly in the creation of complex heterocycles and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting CNS and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its electron-deficient aromatic structure.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig amination, facilitating the construction of complex biaryl systems.
• Nucleophilic Aromatic Substitution: The activated nitro and fluoro groups make it a reactive electrophile for substitution reactions, useful for introducing diverse functionalities.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized fluorinated dyes and pigments with unique optical properties.

Basic Information

Item	Detail
Product Name	2-Fluoro-1-Nitro-4-(Trifluoromethoxy)Benzene
CAS No.	123572-64-5
Molecular Formula	C7H3F4NO3
Molecular Weight	225.10 g/mol
Synonyms	1-Fluoro-2-nitro-4-(trifluoromethoxy)benzene; 4-(Trifluoromethoxy)-2-fluoronitrobenzene; 2-Fluoro-4-(trifluoromethoxy)nitrobenzene; 2-Fluoro-1-nitro-4-(trifluoromethoxy)benzene; 2-Fluoro-4-trifluoromethoxynitrobenzene; 2-Fluoro-α,α,α-trifluoro-p-nitrophenyl methyl ether; 2-Fluoro-4-(trifluoromethoxy)-1-nitrobenzene
EINECS	Contact for details

Quality Control

Our 2-Fluoro-1-Nitro-4-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container must be kept tightly sealed due to the compound's sensitivity to light and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.