Description

(11β,16β)-21-Ethoxy-9-Fluoro-11-Hydroxy-16-Methyl-17-(1-Oxopropoxy)-Pregna-1,4-Diene-3,20-Dione CAS NO 123013-29-6 is a high-purity synthetic corticosteroid derivative, specifically engineered for advanced pharmaceutical research and development. This compound is critical for its potent anti-inflammatory and immunosuppressive properties, serving as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of next-generation therapeutic agents. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions focused on developing novel treatments for dermatological, ophthalmic, and systemic inflammatory conditions.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the multi-step synthesis of potent topical and systemic corticosteroids.
• Active Pharmaceutical Ingredient (API) Research: Used in preclinical and clinical research for developing new anti-inflammatory and immunosuppressive drugs.
• Dermatological Formulations: A key component in the R&D of creams, ointments, and lotions for treating eczema, psoriasis, and dermatitis.
• Ophthalmic Solutions: Investigated for use in eye drops and suspensions to manage inflammatory eye conditions.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Utilized in studies to understand glucocorticoid receptor interactions and metabolic pathways.

Basic Information

Product Name	(11β,16β)-21-Ethoxy-9-Fluoro-11-Hydroxy-16-Methyl-17-(1-Oxopropoxy)-Pregna-1,4-Diene-3,20-Dione
CAS No.	123013-29-6
Molecular Formula	C₂₇H₃₅FO₇
Molecular Weight	490.56 g/mol
Synonyms	9-Fluoro-11β,16β,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 17,21-dipropionate; Difluprednate Impurity; Difluprednate Related Compound C; 21-Ethoxy-9-fluoro-11β-hydroxy-16β-methyl-17α-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; (11β,16β)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate; Durezol Impurity; Corticosteroid Intermediate 123013-29-6
EINECS	Contact for details

Quality Control

Every batch of (11β,16β)-21-Ethoxy-9-Fluoro-11-Hydroxy-16-Methyl-17-(1-Oxopropoxy)-Pregna-1,4-Diene-3,20-Dione is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency that meet the stringent requirements for pharmaceutical intermediates and reference standards. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.