Description

2,5-Difluoro-1,3-Dicarbonitrile CAS NO 122546-74-1 is a high-purity, versatile difluorinated aromatic building block essential for advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and reactive nitrile groups, enabling precise molecular modifications to enhance the properties of target compounds. This intermediate is critically needed by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), where fluorine incorporation can improve metabolic stability, bioavailability, and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging fluorine's ability to enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a core building block for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties, thermal stability, and optical performance.
• Polymer & Specialty Chemicals: Incorporated into high-performance polymers, resins, and specialty chemicals to impart unique characteristics such as chemical resistance, low surface energy, and thermal stability.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) due to the presence of fluorine substituents, allowing for further functionalization.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial research focused on exploring new methodologies in fluorination and heterocyclic chemistry.

Basic Information

Product Name	2,5-Difluoro-1,3-Dicarbonitrile
CAS No.	122546-74-1
Molecular Formula	C8H2F2N2
Molecular Weight	164.11 g/mol
Synonyms	1,3-Dicyano-2,5-difluorobenzene; 2,5-Difluorobenzene-1,3-dicarbonitrile; 2,5-Difluoroisophthalonitrile; 2,5-Difluoro-1,3-benzenedicarbonitrile; Isophthalonitrile, 2,5-difluoro-; Benzene-1,3-dicarbonitrile, 2,5-difluoro-; 2,5-Difluorobenzene-m-dicarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 2,5-Difluoro-1,3-Dicarbonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent exposure to atmospheric moisture, which can affect product quality and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.