Description

(S)-(+)-Dimethindene Maleate CAS NO 121367-05-3 is the single enantiomer of the well-known antihistaminic agent, dimethindene maleate. This specific stereoisomer is of significant interest in advanced pharmaceutical research and development due to its targeted pharmacological activity. It is primarily utilized by pharmaceutical manufacturers and research institutions for the development of enantiomerically pure active pharmaceutical ingredients (APIs), chiral reference standards, and novel therapeutic agents.

Application

• Active Pharmaceutical Ingredient (API) for enantiomerically pure antihistamine formulations.
• Chiral reference standard and building block in pharmaceutical R&D for allergy and inflammation research.
• Key intermediate in the synthesis of novel, stereoselective receptor antagonists.
• Critical material for analytical method development and validation in quality control laboratories.
• Research chemical for pharmacological studies investigating the specific effects of the (S)-enantiomer.
• Starting material for the preparation of deuterated or other isotopically labeled analogs for metabolic studies.

Basic Information

Product Name	(S)-(+)-Dimethindene Maleate
CAS No.	121367-05-3
Molecular Formula	C20H24N2 • C4H4O4
Molecular Weight	408.47 g/mol
Synonyms	(S)-(+)-Dimethindene Maleate; (S)-Dimethindene Maleate; (+)-Dimethindene Maleate; (S)-1-[2-[1-(4-tert-Butylphenyl)ethyl]-3-indenyl]ethyl]pyridine Maleate; Forhistal (enantiomer); Fenistil (enantiomer); Dimethindene (S)-(+)-isomer Maleate Salt; CAS 3614-69-5 (base)
EINECS	Contact for details

Quality Control

Our (S)-(+)-Dimethindene Maleate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, chiral purity, related substances, residual solvents, and other critical parameters. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to protect from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Individual unknown impurity ≤0.10% Total impurities ≤1.0%
Water (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.