Description

Fluorodaunorubicine CAS NO 121351-02-8 is a fluorinated derivative of the anthracycline antibiotic daunorubicin, designed to enhance therapeutic efficacy and alter pharmacokinetic properties. This compound is of significant interest for its potential in advanced oncology research and targeted drug development. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and manufacturers of active pharmaceutical ingredients (APIs) focused on next-generation cancer therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel anthracycline-based chemotherapeutic agents.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of action, drug resistance, and structure-activity relationships (SAR) of fluorinated anticancer drugs.
• API Synthesis: Employed in the controlled synthesis of high-potency active pharmaceutical ingredients for experimental and clinical-stage formulations.
• Bioconjugation Studies: Acts as a model compound for developing antibody-drug conjugates (ADCs) or other targeted delivery systems.
• Metabolic Pathway Analysis: Utilized in research to study the metabolic fate and biotransformation of fluorinated analogues in biological systems.

Basic Information

Product Name	Fluorodaunorubicine
CAS No.	121351-02-8
Molecular Formula	C27H29FNO10
Molecular Weight	546.52 g/mol
Synonyms	4'-Fluorodaunorubicin; 4'-Fluoro-13-dihydrodaunorubicin; 4'-F-DNR; Daunorubicin 4'-fluoro derivative; (8S,10S)-8-Acetyl-10-[(2S,4S,5S,6S)-4-amino-5-fluoro-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione
EINECS	Contact for details

Quality Control

Our Fluorodaunorubicine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR), and control of specified impurities. A detailed Certificate of Analysis (COA) is provided, confirming compliance with in-house specifications tailored for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Assay (HPLC)	95.0% - 105.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.