Description

14-Chlorodaunorubicin is a chemically modified derivative of the anthracycline antibiotic daunorubicin, distinguished by the introduction of a chlorine atom at the 14-position. This structural modification is of significant interest in pharmaceutical research for its potential to alter biological activity, metabolic stability, and interaction with therapeutic targets. It serves as a critical pharmaceutical intermediate and reference standard for researchers and developers in oncology drug discovery and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel anthracycline-based chemotherapeutic agents and prodrugs.
• Oncology Research: Used as a reference compound in biochemical and pharmacological studies to investigate structure-activity relationships (SAR) and mechanisms of action against cancer cells.
• Medicinal Chemistry: Serves as a precursor for further chemical modifications aimed at developing new analogs with improved efficacy or reduced side effects.
• Biochemical Tool: Employed in laboratory studies to understand DNA intercalation, topoisomerase II inhibition, and cellular apoptosis pathways.
• Reference Standard: Utilized in analytical laboratories for method development, validation, and quality control of related pharmaceutical substances.
• Academic & Institutional Research: Supports fundamental research in universities and institutes focused on anticancer drug development.

Basic Information

Product Name	14-Chlorodaunorubicin
CAS No.	121250-06-4
Molecular Formula	C27H30ClNO10
Molecular Weight	564.0 g/mol
Synonyms	14-Chloro-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; 14-Chloro-13-dihydrodaunorubicin; 14-Cl-DNR; Daunorubicin, 14-chloro-; 14-Chlorodaunomycin; 14-Chlororubicin; 14-Chloro-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
EINECS	Contact for details

Quality Control

Our 14-Chlorodaunorubicin is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure it meets the stringent requirements for research and development use. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.