Description

7-Azidoactinomycin D is a chemically modified derivative of the potent antitumor antibiotic Actinomycin D, where an azido functional group has been introduced. This modification is critical for creating photoaffinity probes and bioconjugates used in advanced biochemical and pharmacological research. It is primarily utilized by research scientists and pharmaceutical developers in the fields of cancer research, molecular biology, and drug discovery for studying nucleic acid interactions and developing targeted therapies.

Application

• Photoaffinity Labeling: Acts as a crucial probe for studying the binding sites and mechanisms of action of actinomycin derivatives with DNA and other biological targets.
• Bioconjugation & Probe Development: Serves as a key intermediate for synthesizing fluorescent or affinity-tagged derivatives for imaging and pull-down assays.
• Anticancer Research: Used in mechanistic studies to investigate the inhibition of transcription and DNA replication, aiding in the development of novel chemotherapeutic agents.
• Biochemical Tool Compound: Employed in vitro to selectively inhibit RNA polymerase and study gene expression regulation.
• Academic & Pharmaceutical R&D: Essential for fundamental research in universities, research institutes, and drug discovery pipelines focused on oncology.

Basic Information

Product Name	7-Azidoactinomycin D
CAS No.	121051-59-0
Molecular Formula	C62H86N12O16
Molecular Weight	1279.44 g/mol
Synonyms	7-Azidoactinomycin D; 7-Azido-Dactinomycin; 7-N3-Actinomycin D; Azidoactinomycin D; Actinomycin D Azide Derivative; 7-Azido-actinomycin D; Photoactivatable Actinomycin D; CAS 121051-59-0
EINECS	Contact for details

Quality Control

Our 7-Azidoactinomycin D is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The compound is light-sensitive (store away from light). Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Red to orange solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.