Description

6α-Methyl Hydrocortisone 21-Hemisuccinate is a high-purity synthetic corticosteroid derivative, specifically engineered as a key pharmaceutical intermediate. This compound is critical for ensuring the precise and reliable synthesis of advanced steroid-based active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of potent anti-inflammatory and immunosuppressive medications.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of advanced corticosteroid APIs.
• Anti-inflammatory Drug Research: Serves as a precursor in the development of novel topical and systemic anti-inflammatory agents.
• Immunosuppressant Synthesis: Used in the manufacturing pathway for drugs designed to modulate immune system response.
• Reference Standard: Employed as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical labs.
• Process Chemistry: Integral to scale-up and optimization studies for the commercial production of steroid derivatives.
• Biochemical Research: Used in studies investigating glucocorticoid receptor interactions and metabolic pathways.

Basic Information

Product Name	6α-Methyl Hydrocortisone 21-Hemisuccinate
CAS No.	119657-85-1
Molecular Formula	C26H36O8
Molecular Weight	476.56 g/mol
Synonyms	6α-Methylhydrocortisone 21-hemisuccinate; 6α-Methylcortisol 21-hemisuccinate; (6α,11β)-11,17,21-Trihydroxy-6-methylpregn-4-ene-3,20-dione 21-hemisuccinate; 6α-Methyl-11β,17α,21-trihydroxypregn-4-ene-3,20-dione 21-hemisuccinate; 6α-Methylprednisolone 21-hemisuccinate (common name); 6α-Methyl Hydrocortisone Hemisuccinate
EINECS	Contact for details

Quality Control

Our 6α-Methyl Hydrocortisone 21-Hemisuccinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation via IR and NMR, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.