Description

Nebivolol (S,S,S,S)-Isomer CAS NO 119365-28-5 is the pharmacologically active enantiomer of the β-blocker Nebivolol, characterized by its specific stereochemical configuration. This high-purity isomer is critical for pharmaceutical research and development, enabling precise pharmacological studies and the production of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical manufacturers, R&D laboratories, and academic institutions focused on cardiovascular drug development, analytical method validation, and chiral synthesis.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Key intermediate for the manufacture of enantiomerically pure Nebivolol hydrochloride.
• Pharmacological & Clinical Research: Used in studies to isolate and understand the specific cardiovascular effects attributed to the (S,S,S,S)-isomer.
• Analytical Reference Standard: Serves as a certified reference material (CRM) for HPLC, LC-MS, and chiral assay development and validation.
• Process Chemistry & Method Development: Employed in optimizing asymmetric synthesis routes and purification processes for chiral drugs.
• Regulatory Submissions: Used to generate impurity profiles and stability data for drug master files (DMFs) and regulatory dossiers (e.g., for FDA, EMA).
• Academic & Institutional Research: Fundamental research in medicinal chemistry, stereochemistry, and β-adrenergic receptor pharmacology.

Basic Information

Product Name	Nebivolol (S,S,S,S)-Isomer
CAS No.	119365-28-5
Molecular Formula	C22H25F2NO4
Molecular Weight	405.44 g/mol
Synonyms	(S,S,S,S)-Nebivolol; d-Nebivolol; Nebivolol Enantiomer; (2R,2'S,2''S)-1,1'-[(2R,2'S,2''S)-2,2''-Bis(6-fluorochroman-2-yl)-2,2''-ethanediyl]bis[3-(2-cyclopentyl-2-hydroxyethylamino)-2-propanol]; Bystolic Isomer; R 065-824 Isomer
EINECS	Contact for details

Quality Control

Our Nebivolol (S,S,S,S)-Isomer is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent in-house specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We support cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.