Description

(2-Fluoro-4,5-Dimethoxyphenyl)-(R)-Hydroxyacetonitrile is a high-value, chiral synthetic intermediate characterized by its fluorinated and dimethoxylated aromatic structure. This compound is critical for its role in the enantioselective synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of potential drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced, enantiomerically pure herbicides, fungicides, and pesticides.
• Asymmetric Catalysis Research: Serves as a valuable substrate or ligand precursor in the study and development of new chiral catalysts.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals and complex organic molecules requiring high stereochemical purity.
• Academic & Industrial R&D: Utilized in research laboratories for methodological development and exploring new chemical spaces in medicinal chemistry.

Basic Information

Product Name	(2-Fluoro-4,5-Dimethoxyphenyl)-(R)-Hydroxyacetonitrile
CAS No.	119085-63-1
Molecular Formula	C10H10FNO3
Molecular Weight	211.19 g/mol
Synonyms	(R)-2-(2-Fluoro-4,5-dimethoxyphenyl)-2-hydroxyacetonitrile; (R)-Mandelonitrile, 2-fluoro-4,5-dimethoxy-; (R)-α-Hydroxy-2-fluoro-4,5-dimethoxybenzeneacetonitrile; (R)-2-Fluoro-4,5-dimethoxymandelonitrile; (2R)-2-(2-Fluoro-4,5-dimethoxyphenyl)-2-hydroxyacetonitrile; (R)-Hydroxy(2-fluoro-4,5-dimethoxyphenyl)acetonitrile; (R)-Enantiomer of 2-Fluoro-4,5-dimethoxymandelonitrile
EINECS	Contact for details

Quality Control

We supply (2-Fluoro-4,5-Dimethoxyphenyl)-(R)-Hydroxyacetonitrile in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) providing detailed specifications for chiral purity, chemical purity, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (R)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.