Description

Prednisone Sodium Succinate is a water-soluble, injectable prodrug form of the potent glucocorticoid prednisone. This formulation is critical for enabling rapid systemic administration in clinical settings where immediate therapeutic action is required. It is primarily utilized by pharmaceutical manufacturers and compounding facilities for the production of sterile injectable solutions targeting severe inflammatory and autoimmune conditions.

Application

• Pharmaceutical Active Ingredient: Primary use in the formulation of sterile injectable corticosteroid medications for hospital and emergency use.
• Acute Inflammatory Disease Management: Key component in drugs designed to rapidly suppress inflammation in conditions such as severe allergic reactions, asthma exacerbations, and acute episodes of autoimmune diseases.
• Oncology Supportive Care: Used in chemotherapeutic regimens to manage inflammation, reduce edema associated with tumors, and mitigate certain side effects of cancer treatments.
• R&D and Reference Standard: Serves as a critical reference material in pharmaceutical research, development, and quality control laboratories for analytical method development and validation.
• Veterinary Pharmaceuticals: Employed in the development of anti-inflammatory and immunosuppressive treatments for animals.

Basic Information

Product Name	Prednisone Sodium Succinate
CAS No.	119042-10-3
Molecular Formula	C26H31NaO8
Molecular Weight	494.51 g/mol
Synonyms	Prednisolone 21-Sodium Succinate; Prednisone 21-Hemisuccinate Sodium Salt; Sodium Prednisone Succinate; NSC-100880; 11β,17α,21-Trihydroxypregna-1,4-diene-3,11,20-trione 21-(sodium succinate); Soluble Prednisone; Prednisolone Sodium Succinate (related prodrug)
EINECS	Contact for details

Quality Control

Our Prednisone Sodium Succinate is manufactured and tested under a quality management system to ensure it meets the stringent requirements for pharmaceutical intermediates. Each batch is subjected to comprehensive analytical testing, including identity, purity, and impurity profile determination via advanced techniques like HPLC. Certificates of Analysis (COA) documenting compliance with agreed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The original container should be resealed immediately after use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
pH (5% solution)	6.5 - 8.5
Bacterial Endotoxins	< 0.17 EU/mg (for injectable grade)
Sterility	Sterile (for sterile-fill grade, upon request)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.