Description

Vorozole is a potent, non-steroidal, third-generation aromatase inhibitor, a key compound in advanced pharmaceutical research and development. Its primary value lies in its selective inhibition of the aromatase enzyme, which is critical for the biosynthesis of estrogens from androgens. This makes it an essential research chemical for scientists and manufacturers developing novel therapeutic agents, particularly in the fields of oncology and endocrinology, targeting hormone-dependent conditions.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs) for hormone therapy.
• Biochemical Research: Used as a reference standard and tool compound in preclinical studies to investigate aromatase enzyme kinetics and inhibition mechanisms.
• Oncology R&D: Fundamental for developing and testing new therapeutic strategies for estrogen receptor-positive (ER+) cancers, including breast and ovarian cancer.
• Endocrine Disorder Studies: Applied in research models to understand and treat conditions influenced by estrogen levels.
• Veterinary Medicine Development: Explored for potential applications in treating hormone-dependent conditions in animals.

Basic Information

Product Name	Vorozole
CAS No.	118949-22-7
Molecular Formula	C₁₇H₁₉N₅
Molecular Weight	293.37 g/mol
Synonyms	R 83842; (R)-(-)-6-[(4-Chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H-benzotriazole; (-)-Vorozole; (R)-Vorozole; R-83842; UNII-0QJ2I3K2VU; 1H-Benzotriazole, 6-[(4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-, (R)-
EINECS	Contact for details

Quality Control

Our Vorozole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet rigorous research-grade specifications. A Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.