Description

3-Fd-Daunomycin is a fluorinated derivative of the potent anthracycline antibiotic, daunomycin, designed to enhance its therapeutic profile and research utility. This compound is of significant interest for its potential to modulate biological activity and improve pharmacokinetic properties compared to the parent molecule. It serves as a critical intermediate and reference standard for pharmaceutical R&D, particularly in oncology and biochemistry. Researchers and manufacturers in the fields of anticancer drug development and molecular biology utilize this specialized chemical for advanced studies and synthesis.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of novel anthracycline-based chemotherapeutic agents.
• Biochemical Studies: Used as a reference standard and probe to investigate DNA intercalation mechanisms, topoisomerase II inhibition, and cellular apoptosis pathways.
• Anticancer Agent Development: Explored for its potential to overcome drug resistance or reduce cardiotoxicity associated with traditional anthracyclines.
• Academic Research: Employed in university and institutional labs for studying structure-activity relationships (SAR) of fluorinated bioactive compounds.
• Analytical Standard: Utilized in HPLC, LC-MS, and NMR for method development, validation, and quality control of related pharmaceutical substances.

Basic Information

Product Name	3-Fd-Daunomycin
CAS No.	118243-77-9
Molecular Formula	C27H29FNO10
Molecular Weight	546.52 g/mol
Synonyms	3'-Fluoro-3'-deoxydaunomycin; 3'-Fluoro-3'-deoxydaunorubicin; 3'-F-DNR; 3'-Fluorodaunorubicin; 3'-Fluoro-3'-deoxy-13-dihydrodaunorubicin; Daunomycin 3'-fluoro-3'-deoxy derivative; 3'-F-Daunomycin; 3-Fluoro-3-deoxydaunorubicin
EINECS	Contact for details

Quality Control

Our 3-Fd-Daunomycin is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the label. This product is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.