Description

2-Fluoro-4-Demethoxydaunomycin is a fluorinated analog of the anthracycline antibiotic daunomycin, representing a key intermediate in the development of novel chemotherapeutic agents. This compound is of significant interest for its potential to modulate biological activity and reduce cardiotoxicity compared to its parent molecule. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of advanced oncology drug candidates and for biochemical research into DNA intercalation mechanisms.

Application

• Pharmaceutical Intermediate: Critical building block in the research and synthesis of next-generation anthracycline-based anticancer drugs.
• Biochemical Research: Used as a reference standard and probe in studies investigating DNA-binding interactions, topoisomerase II inhibition, and mechanisms of drug resistance.
• Medicinal Chemistry: Serves as a core scaffold for structural-activity relationship (SAR) studies aimed at improving therapeutic index and reducing side effects.
• Academic Research: Employed in university and institutional labs for fundamental research in oncology, pharmacology, and organic synthesis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	2-Fluoro-4-Demethoxydaunomycin
CAS No.	118243-76-8
Molecular Formula	C₂₆H₂₅FNO₉
Molecular Weight	514.48 g/mol
Synonyms	2-Fluoro-4-demethoxy-daunorubicin; 2'-Fluoro-4'-demethoxydaunomycin; 2-Fluoro-4-demethoxy-13-dihydrodaunomycinone; 2-Fluoro-4-demethoxydaunorubicin; 2-Fluoro-4-demethoxy-13-dihydrodaunorubicin; 2-Fluoro-4-demethoxy-13-dihydrodaunomycin; 2-Fluoro-4-demethoxy-13-dihydro-7,9,11-trihydroxy-4-methoxy-8-methyl-13-oxo-5,12-naphthacenedione
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Demethoxydaunomycin is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.