Description

3-Chloro-4-Fluorobenzonitrile is a versatile halogenated benzonitrile derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents, makes it a valuable intermediate for introducing specific electronic and steric properties into target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the chloro-fluoro substitution pattern enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies, contributing to improved dielectric anisotropy and response times.
• Polymer Chemistry: Acts as a monomer or functionalization agent for creating high-performance polymers with specific thermal and chemical resistance properties.
• Organic Electronics: Utilized in the synthesis of electron-transport materials and organic semiconductors for OLEDs and photovoltaic cells.
• Chemical Research: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to construct complex aromatic systems in academic and industrial R&D.

Basic Information

Product Name	3-Chloro-4-Fluorobenzonitrile
CAS No.	117482-84-5
Molecular Formula	C7H3ClFN
Molecular Weight	155.56 g/mol
Synonyms	4-Fluoro-3-chlorobenzonitrile; 3-Chloro-4-fluorobenzene carbonitrile; 3-Chloro-4-fluorophenyl cyanide; Benzonitrile, 3-chloro-4-fluoro-; 1-Chloro-2-fluoro-4-cyanobenzene; 2-Fluoro-6-chlorobenzonitrile; (3-Chloro-4-fluorophenyl)methanenitrile
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluorobenzonitrile is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	65 - 68 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.