Description

1,2-Difluoro-4-Nitro-5-(Trifluoromethyl)Benzene is a high-value, multi-functional fluorinated aromatic building block. This compound is critical for introducing both nitro and trifluoromethyl substituents into complex molecular architectures, enabling precise tuning of electronic and steric properties. It is primarily sought after by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of advanced active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the nitro and trifluoromethyl groups contribute to biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Functional Material Research: Employed in academic and industrial R&D for creating specialty polymers, ligands, and catalysts with tailored properties.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex biaryl systems.

Basic Information

Product Name	1,2-Difluoro-4-Nitro-5-(Trifluoromethyl)Benzene
CAS No.	117392-82-2
Molecular Formula	C7H2F5NO2
Molecular Weight	227.09 g/mol
Synonyms	2,3-Difluoro-4-nitrobenzotrifluoride; 4-Nitro-2,3-bis(trifluoromethyl)benzene (incorrect but common misnomer); 1,2-Difluoro-4-nitro-5-(trifluoromethyl)benzene; 5-(Trifluoromethyl-1,2-difluoro-4-nitrobenzene; 2,3-Difluoro-4-nitro-alpha,alpha,α-trifluorotoluene; Benzene, 1,2-difluoro-4-nitro-5-(trifluoromethyl)-; 4-Nitro-2,3-difluorobenzotrifluoride
EINECS	Contact for details

Quality Control

Our 1,2-Difluoro-4-Nitro-5-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.