Description

14-Salicyloylcarubicin is a chemically modified derivative of the anthracycline antibiotic, doxorubicin, designed for enhanced research and development applications. This compound is of significant interest in the field of medicinal chemistry and oncology research due to its potential for improved pharmacological properties and targeted activity. It serves as a critical intermediate and reference standard for pharmaceutical R&D, particularly in the synthesis and study of novel anti-cancer agents. Researchers and developers in the pharmaceutical and biotechnology sectors require this high-purity compound for advanced therapeutic exploration.

Application

• Pharmaceutical Research & Development: Key intermediate in the synthesis of novel anthracycline-based chemotherapeutic agents.
• Oncology Drug Discovery: Reference standard for studying structure-activity relationships (SAR) to develop more effective and less cardiotoxic cancer treatments.
• Biochemical Research: Tool compound for investigating mechanisms of action, DNA intercalation, and topoisomerase II inhibition.
• Academic & Institutional Research: Used in university and research institute laboratories for fundamental studies in medicinal chemistry and pharmacology.
• Process Development & Scale-up: Serves as a critical material for optimizing synthetic routes and manufacturing processes for advanced pharmaceutical ingredients (APIs).
• Analytical Method Development: High-purity standard for calibrating HPLC, LC-MS, and other analytical instruments used in quality control laboratories.

Basic Information

Product Name	14-Salicyloylcarubicin
CAS No.	116907-26-7
Molecular Formula	C₃₄H₃₅NO₁₄
Molecular Weight	681.64 g/mol
Synonyms	14-O-Salicyloyldoxorubicin; 14-Salicyloyldoxorubicin; 14-Salicyloyl-doxorubicin; Salicyloylcarubicin; 14-Salicyloyl-doxorubicin; Doxorubicin 14-salicylate; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione 14-salicylate
EINECS	Contact for details

Quality Control

Our 14-Salicyloylcarubicin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, identity confirmation by IR and MS, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with relevant guidelines for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.