Description

(R)-2-(Trifluoromethylsulfonyloxy)Propionic Acid Methyl Ester is a high-value chiral building block and triflating reagent of significant importance in advanced organic synthesis. Its core value lies in its ability to introduce the trifluoromethanesulfonate (triflate) group, a premier leaving group, with high stereochemical fidelity, enabling the construction of complex, optically active molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), novel drug candidates, and specialty fine chemicals where stereochemistry is critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the stereoselective synthesis of complex APIs, including antiviral, anticancer, and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Triflation Reagent: Serves as a specialized reagent for converting alcohols into their corresponding triflates, which are highly reactive intermediates in cross-coupling reactions (e.g., Suzuki, Negishi).
• Asymmetric Synthesis: Employed in catalytic asymmetric transformations and the preparation of chiral ligands or catalysts for stereocontrolled processes.
• Material Science Research: Utilized in the synthesis of advanced organic materials and liquid crystals where specific optical properties are required.
• Process Chemistry & Scale-up: Suitable for development from laboratory-scale research to pilot plant and commercial manufacturing of high-value specialty chemicals.

Basic Information

Product Name	(R)-2-(Trifluoromethylsulfonyloxy)Propionic Acid Methyl Ester
CAS No.	115724-80-6
Molecular Formula	C5H7F3O5S
Molecular Weight	236.17 g/mol
Synonyms	(R)-Methyl 2-(((trifluoromethyl)sulfonyl)oxy)propanoate; (R)-Methyl 2-((trifluoromethanesulfonyl)oxy)propionate; Methyl (R)-2-(triflyloxy)propionate; (R)-2-(Trifluoromethanesulfonyloxy)propionic Acid Methyl Ester; (R)-Methyl Lactate Triflate; (R)-α-Trifluoromethanesulfonyloxy Propionic Acid Methyl Ester; (R)-Methyl 2-OTf-propionate
EINECS	Contact for details

Quality Control

Our (R)-2-(Trifluoromethylsulfonyloxy)Propionic Acid Methyl Ester is manufactured under strict quality control protocols to ensure high chemical and enantiomeric purity, which is critical for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) for each batch, detailing key parameters such as assay, enantiomeric excess (e.e.), and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for customers in regulated industries, ensuring traceability and consistency for your development and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.