Description

18,19-Dihydroxycorticosterone is a specialized corticosteroid derivative of significant interest in biochemical and pharmaceutical research. This compound serves as a critical intermediate and reference standard for the study of steroid hormone metabolism, biosynthesis, and receptor interactions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and contract manufacturing organizations (CMOs) engaged in advanced endocrinology, drug discovery, and analytical method development.

Application

• Pharmaceutical Research & Development: Acts as a key intermediate in the synthesis and study of novel corticosteroid analogs and metabolites.
• Biochemical Reference Standard: Used for the calibration of analytical instruments (HPLC, LC-MS) and as a qualitative standard in method validation for steroid analysis.
• Metabolic Pathway Studies: Employed in in vitro and in vivo research to investigate the enzymatic pathways of corticosterone metabolism.
• Endocrinology Research: Serves as a tool compound for probing glucocorticoid and mineralocorticoid receptor activity and signaling mechanisms.
• Academic Research: Utilized in university and institutional labs for fundamental studies in steroid chemistry and hormone biology.
• Quality Control: Functions as a high-purity standard for the quality assurance testing of related steroid APIs and finished pharmaceutical products.

Basic Information

Product Name	18,19-Dihydroxycorticosterone
CAS No.	115288-31-8
Molecular Formula	C₂₁H₃₀O₆
Molecular Weight	378.46 g/mol
Synonyms	18,19-Dihydroxycorticosterone; 11β,21-Dihydroxypregn-4-ene-3,18,19,20-tetrone; 18,19-Dihydroxy-11-dehydrocorticosterone; 18,19-Dihydroxy-4-pregnene-3,11,20-trione; Corticosterone-18,19-diol; 18,19-Dihydroxy-11-deoxycorticosterone (related derivative); 11-Dehydrocorticosterone-18,19-diol
EINECS	Contact for details

Quality Control

Our 18,19-Dihydroxycorticosterone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. The compound is light-sensitive; handle under appropriate conditions to minimize degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.