Description

Aconityldoxorubicin CAS NO 114390-31-7 is a chemically modified derivative of the potent anthracycline antibiotic, doxorubicin. This compound is of significant interest in pharmaceutical research and development, particularly for its potential to alter the pharmacokinetic profile and reduce the cardiotoxicity associated with the parent molecule. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel oncology therapeutics and targeted drug delivery systems.

Application

• Oncology Research: Serves as a key intermediate or active pharmaceutical ingredient (API) in preclinical studies for novel anti-cancer agents.
• Drug Conjugate Development: Used in the synthesis of antibody-drug conjugates (ADCs) or other targeted prodrugs due to its modifiable chemical structure.
• Pharmacology Studies: Employed to investigate structure-activity relationships (SAR) and mechanisms of action of anthracycline derivatives.
• Toxicity Mitigation Research: A candidate molecule in studies aimed at developing chemotherapeutic agents with improved safety profiles.
• Academic & Institutional Research: Used in university and government labs for fundamental chemical and biological research on anthracyclines.

Basic Information

Product Name	Aconityldoxorubicin
CAS No.	114390-31-7
Molecular Formula	C32H35NO14
Molecular Weight	657.62 g/mol
Synonyms	14-O-[(3-Carboxy-1-oxo-2-propenyl)doxorubicin]; Doxorubicin 14-O-(3-carboxyacryloyl) ester; Aconityl doxorubicin; Aconitic acid doxorubicin ester; NSC 357704; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione 14-(3-carboxy-2-propenoate)
EINECS	Contact for details

Quality Control

Our Aconityldoxorubicin is manufactured under strict quality control protocols suitable for research and development applications. Each batch is characterized and tested to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, and residual solvents is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Single Unknown Impurity	≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.