Description

Thiophilic Resin (Mercaptoethanol-4%*Bea Ded Agarose) is a specialized affinity chromatography medium designed for the selective purification of antibodies and other immunoglobulins. Its core value lies in its unique thiophilic (sulfur-loving) interaction, which offers high selectivity and recovery rates under mild, non-denaturing elution conditions. This product is essential for biopharmaceutical manufacturers, research laboratories, and diagnostic kit developers requiring efficient and scalable antibody purification processes. The resin is supplied as a suspension in a storage solution to maintain its binding capacity and stability.

Application

• Monoclonal and Polyclonal Antibody Purification from cell culture supernatants, ascites fluid, and serum.
• Immunoglobulin G (IgG) Isolation for downstream research, diagnostics, and therapeutic applications.
• F(ab') and Fc Fragment Separation following enzymatic digestion of antibodies.
• Preparative and Process-Scale Chromatography in GMP and non-GMP bioprocessing environments.
• Sample Preparation for Analytical Techniques such as ELISA, Western Blot, and mass spectrometry.
• Removal of Contaminants and Aggregates to enhance the purity and stability of final antibody products.

Basic Information

Product Name	Thiophilic Resin (Mercaptoethanol-4%*Bea Ded Agarose)
CAS No.	114355-50-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Thiophilic Adsorption Resin; Mercaptoethanol Agarose; T-Gel; Thiophilic Interaction Chromatography Resin; 2-Mercaptoethanol-linked Agarose; T-Gel Resin; Sulfur-affinity Chromatography Medium; TAC Resin
EINECS	Contact for details

Quality Control

Our Thiophilic Resin is manufactured under a quality management system and undergoes rigorous batch testing to ensure consistent performance for critical separations. Key parameters such as ligand density, binding capacity for human IgG, particle size distribution, and flow characteristics are verified. Certificates of Analysis (COA) documenting these specifications are available for every lot. We support compliance with relevant industry standards for research and bioprocessing applications.

Storage

Preserve in a tightly closed container, protected from light. Store the resin suspension at 2-8°C. Do not freeze. The product is easily oxidized; ensure the container is sealed under the provided storage solution to maintain an inert atmosphere and prevent drying of the agarose matrix. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white suspension
Matrix	Cross-linked 4% or 6% Agarose
Ligand	2-Mercaptoethanol
Ligand Density	Contact for details
Binding Capacity (Human IgG)	>20 mg/mL settled gel
Particle Size	45-165 μm
Maximum Flow Rate	300 cm/h
pH Stability	3 - 12 (long term), 2 - 14 (short term)
Storage Solution	20% Ethanol containing 0.1 M NaCl

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.