Description

Carboxy-Terminated Magnetic Particles are functionalized nanomaterials consisting of a superparamagnetic iron oxide core coated with a polymer or silica shell that has been surface-modified with carboxyl (-COOH) groups. This specific functionalization is critical for creating a versatile platform for the covalent immobilization of biomolecules, such as antibodies, proteins, and nucleic acids, via amine-coupling chemistry. These particles are indispensable tools for researchers and manufacturers in the diagnostics, biopharmaceutical purification, and life science research sectors, enabling efficient magnetic separation, target capture, and assay development.

Application

• Diagnostic Assay Development: Used as solid-phase supports in immunoassays (e.g., ELISA, lateral flow tests) and molecular diagnostics for the specific capture and detection of biomarkers.
• Biomolecule Purification: Essential for magnetic bead-based isolation and purification of proteins, antibodies, DNA, RNA, and exosomes from complex biological samples.
• Cell Separation and Sorting: Employed in immunomagnetic cell separation (e.g., MACS® technology) for the positive or negative selection of specific cell populations from blood, tissue, or culture.
• Drug Delivery Systems: Investigated as targeted carriers for therapeutic agents, where the carboxyl groups allow for the conjugation of drugs and targeting ligands.
• Enzyme Immobilization: Serve as magnetically recoverable supports for enzymes in biocatalysis and industrial enzymatic processes.
• Environmental Monitoring: Applied in sample preparation for the magnetic extraction and concentration of contaminants, pathogens, or analytes from water and food samples.
• Academic & Industrial Research: A fundamental tool in biochemistry and molecular biology labs for pull-down assays, chromatin immunoprecipitation (ChIP), and other magnetic bead-based protocols.

Basic Information

Product Name	Carboxy-Terminated Magnetic Particles
CAS No.	105808-73-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Carboxylated magnetic beads; COOH-functionalized magnetic nanoparticles; Carboxy-modified magnetic microspheres; Magnetic particles, carboxyl-terminated; Carboxyl magnetic beads; Magnetic silica particles, carboxylated; Carboxylated iron oxide nanoparticles; Superparamagnetic iron oxide nanoparticles (SPIONs), carboxylated; Dynabeads®-type particles (carboxyl); MACS® MicroBeads (carboxyl)
EINECS	Contact for details

Quality Control

Our Carboxy-Terminated Magnetic Particles are manufactured under a quality management system and undergo rigorous batch-by-batch testing to ensure consistent performance and lot-to-lot reproducibility. Key parameters such as particle size distribution, magnetic content, surface carboxyl group density, and functional performance in biomolecule coupling are strictly controlled. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in the original, tightly closed container as supplied. Store at 2-8°C. Do not freeze. Protect from light. Under these recommended conditions, the product is stable for the period indicated on the label. For long-term storage, keep the container in an upright position to prevent sedimentation.

Specification

Item	Specification
Appearance	Brownish, homogeneous suspension
Core Material	Superparamagnetic Iron Oxide (Fe₃O₄ / γ-Fe₂O₃)
Particle Size (Mean Diameter)	1.0 µm ± 0.2 µm (or other standard sizes available)
Solid Content	10 mg/mL ± 2 mg/mL
Surface Functional Group	Carboxyl (-COOH)
Carboxyl Group Density	≥ 50 µmol/g
Buffer	PBS, pH 7.4, with 0.01% Tween-20 & 0.09% NaN₃
Magnetic Responsiveness	Complete separation within 1-2 minutes in a standard magnetic rack
Biomolecule Binding Capacity	≥ 20 µg IgG per mg beads

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.