Description

Amine-Terminated Magnetic Particles are functionalized nanomaterials consisting of a superparamagnetic iron oxide core coated with a polymer or silica shell that presents primary amine groups on its surface. This unique combination of magnetic responsiveness and reactive amine functionality is critical for the selective capture, separation, and purification of target biomolecules and cells. These particles are essential tools for researchers and manufacturers in the biotechnology, diagnostics, and pharmaceutical industries, enabling high-throughput, automated workflows for applications like immunoassays, nucleic acid extraction, and cell sorting.

Application

• Biomagnetic Separation: For the rapid isolation and purification of proteins, antibodies, DNA, RNA, and exosomes from complex biological samples.
• Diagnostic Assays: As solid-phase supports in automated immunoassay systems (e.g., chemiluminescence immunoassay, CLIA) and point-of-care testing devices.
• Cell Isolation & Sorting: For the positive or negative selection of specific cell populations (e.g., CD4+ T cells, stem cells) using antibody-conjugated magnetic beads in research and cell therapy.
• Enzyme & Catalyst Immobilization: As a magnetically recoverable support for immobilizing enzymes or catalysts, facilitating easy separation and reuse in bioconversion and chemical synthesis.
• Affinity Chromatography: Serving as a magnetically responsive resin for the batch-mode purification of His-tagged proteins or other affinity-tagged molecules.
• Environmental Monitoring: For the magnetic solid-phase extraction (MSPE) of contaminants, pathogens, or specific analytes from water and food samples.
• Drug Delivery Systems: As a functional platform for constructing targeted drug delivery carriers, where the amine groups allow for the conjugation of therapeutic payloads and targeting ligands.

Basic Information

Product Name	Amine-Terminated Magnetic Particles
CAS No.	105808-72-8
Molecular Formula	N/A (Composite Nanomaterial)
Molecular Weight	N/A (Size-Dependent)
Synonyms	Amino-functionalized magnetic beads; Magnetic nanoparticles, amine-modified; NH2-magnetic particles; Amine-coated magnetic microspheres; Magnetic silica particles, amine-terminated; Superparamagnetic iron oxide nanoparticles (SPIONs), amine-functionalized; Magnetic polymer beads with primary amine groups; Magnetic separation beads, amino
EINECS	Contact for details

Quality Control

Every batch of our Amine-Terminated Magnetic Particles is manufactured under a quality management system and subjected to a comprehensive suite of analytical tests. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes key parameters such as particle size distribution (DLS), magnetic content (TGA), surface amine group density (colorimetric assay), and functional performance in a standard binding test. Our production adheres to ISO 13485 principles where applicable, supporting their use in diagnostic and biomedical research.

Storage

Preserve in the original, tightly closed container as supplied. Store at 2-8°C. Do not freeze. Protect from light and moisture. Under these recommended conditions, the product is stable for at least 12 months from the date of receipt. For long-term storage, keep the suspension well-dispersed and avoid prolonged exposure to room temperature.

Specification

Item	Specification
Appearance	Brownish homogeneous suspension
Core Composition	Superparamagnetic Iron Oxide (Fe3O4)
Surface Functional Group	Primary Amine (-NH2)
Mean Particle Size (DLS)	100 nm - 1 µm (Various grades available)
Solid Content	5 - 25 mg/mL (In aqueous buffer)
Amine Group Density	50 - 300 µmol/g (Depending on grade)
Magnetic Responsiveness	Complete separation within 1-5 minutes using a magnet
Buffer	PBS, Tris, or MES buffer, pH 7.0-7.4
Preservative	0.02 - 0.1% Sodium Azide or ProClin™

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.