Description

20-Dihydrofluorometholone is a synthetic corticosteroid derivative, specifically a fluorinated and hydrogenated analog of metholone. This compound is valued for its potent anti-inflammatory and immunosuppressive pharmacological activity, making it a critical intermediate in advanced pharmaceutical synthesis. It is primarily required by research institutions and pharmaceutical manufacturers developing next-generation topical and systemic corticosteroid therapies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel corticosteroid active pharmaceutical ingredients (APIs).
• Research & Development: Used in preclinical and clinical research to study structure-activity relationships (SAR) of fluorinated steroids.
• Anti-inflammatory Drug Development: A precursor for developing potent topical creams, ointments, and ophthalmic solutions targeting dermatological and ocular conditions.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Process Chemistry: Utilized in scaling up and optimizing manufacturing routes for steroid-based pharmaceuticals.

Basic Information

Product Name	20-Dihydrofluorometholone
CAS No.	114260-36-5
Molecular Formula	C22H31FO4
Molecular Weight	378.48 g/mol
Synonyms	9α-Fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 20-Dihydro-9α-fluoro-16α-methylprednisolone; Fluorometholone Impurity; 20-Dihydro-9α-fluoro-16α-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione; 9α-Fluoro-16α-methyl-20-dihydroprednisolone; 20-DHFM; 20-Dihydro-9α-fluoro-16α-methylprednisolone
EINECS	Contact for details

Quality Control

Our 20-Dihydrofluorometholone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available upon request, ensuring compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.