Description

(E)-Olopatadine CAS NO 113806-06-7 is a selective histamine H1-antagonist and mast cell stabilizer, representing a key active pharmaceutical ingredient (API) in modern ophthalmic therapeutics. Its primary commercial value lies in its potent anti-allergic efficacy, providing rapid and long-lasting relief from ocular itching and redness. This compound is essential for pharmaceutical manufacturers developing prescription and over-the-counter eye drops for the treatment of allergic conjunctivitis and other inflammatory eye conditions.

Application

• Primary Active Pharmaceutical Ingredient (API) in anti-allergic ophthalmic solutions and suspensions.
• Formulation of prescription eye drops for the treatment of allergic conjunctivitis.
• Key component in over-the-counter (OTC) allergy relief eye drop products.
• Used in clinical research and development of novel topical anti-inflammatory medications.
• Potential intermediate in the synthesis of related antihistamine compounds for pharmaceutical use.

Basic Information

Product Name	(E)-Olopatadine
CAS No.	113806-06-7
Molecular Formula	C21H23NO3
Molecular Weight	337.42 g/mol
Synonyms	Olopatadine (E)-isomer; (11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid; KW-4679; AL-4943A; Patanol (API); Pataday (API); Pazeo (API)
EINECS	Contact for details

Quality Control

Our (E)-Olopatadine is manufactured under strict quality management systems, targeting compliance with pharmaceutical-grade standards. Each batch undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to ensure identity, purity, and strength. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.