Description

Calicheamicin is a potent enediyne antitumor antibiotic originally isolated from the bacterium Micromonospora echinospora ssp. calichensis. Its unique molecular architecture allows it to bind to the minor groove of DNA and cause double-strand breaks, making it a highly effective payload for targeted cancer therapies. This compound is primarily utilized by pharmaceutical research and development organizations, as well as bioconjugation specialists, for the development of antibody-drug conjugates (ADCs) and other innovative oncology treatments.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as the cytotoxic warhead in ADCs, such as gemtuzumab ozogamicin, targeting specific cancer cells.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical research for novel cancer therapeutics.
• Bioconjugation Chemistry: A key intermediate for developing linker-payload systems due to its cleavable hydrazone linkage.
• Mechanistic Studies: Employed in biochemical research to study DNA damage and repair mechanisms in cancer cells.
• Pharmaceutical Synthesis: Used in the synthesis and process development of advanced, targeted chemotherapeutic agents.

Basic Information

Item	Detail
Product Name	Calicheamicin
CAS No.	113440-58-7
Molecular Formula	C55H74IN3O21S4
Molecular Weight	1368.33 g/mol
Synonyms	Calicheamicin γ1; Calicheamicin gamma 1; LL-E33288 gamma 1; N-acetyl-γ-calicheamicin; CMA-676 payload; (1S,2R,3S,4S,7S,8S,10S,13S,14R,15R,16R)-14-[[(2R,3S,4S,6S)-3-[(2S,3S,4S,6S)-3-Acetamido-4,6-dihydroxy-5-(hydroxymethyl)oxan-2-yl]oxy-4,6-dihydroxyoxan-2-yl]oxy]-13-[(2R,3S,4S,5S,6S)-4,5-dihydroxy-3-[(2-hydroxyethyl)sulfanyl]-6-(hydroxymethyl)oxan-2-yl]oxy-2-ethyl-1,10,15-trihydroxy-5,5,8,16-tetramethyl-3,9-dioxo-4,7-dioxapentacyclo[10.8.0.02,10.04,8.013,17]icosa-14,17-dien-6-yl N-[(2R,3S,4S,5S,6S)-5-[(2S,3S,4S,5S,6S)-5-[(2S,3S,4S,5S,6S)-5-[(2S,3S,4S,5S,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our Calicheamicin is manufactured under strict quality systems to ensure the high purity and consistency required for pharmaceutical development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles via advanced analytical techniques. We adhere to cGMP (current Good Manufacturing Practice) standards where applicable, ensuring traceability and reliability for critical research and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Individual Unknown Impurity	≤ 1.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.