Description

Diethyl 2-(2,4,5-Trifluoro-3-Methoxybenzoyl)Malonate is a high-value fluorinated organic intermediate with a complex molecular architecture. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceutical and agrochemical active ingredients. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules containing a trifluoromethoxy-substituted aromatic core.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology drugs.
• Agrochemical Synthesis: Serves as a vital building block for developing novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Material Science Research: Used in the development of advanced organic materials, including liquid crystals and organic semiconductors, due to its electron-withdrawing fluorinated aromatic system.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring fluorinated benzoyl malonate chemistry.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic synthesis, exploring new C-C bond formation reactions and fluorination chemistry.

Basic Information

Product Name	Diethyl 2-(2,4,5-Trifluoro-3-Methoxybenzoyl)Malonate
CAS No.	112811-67-3
Molecular Formula	C15H15F3O6
Molecular Weight	348.27 g/mol
Synonyms	Diethyl (2,4,5-Trifluoro-3-methoxybenzoyl)malonate; 2,4,5-Trifluoro-3-methoxybenzoylmalonic Acid Diethyl Ester; Malonic acid, (2,4,5-trifluoro-3-methoxybenzoyl)-, diethyl ester; Diethyl (2,4,5-Trifluoro-3-methoxyphenyl)-oxoacetate Malonate; Ethyl 2-(2,4,5-Trifluoro-3-methoxybenzoyl)malonate
EINECS	Contact for details

Quality Control

Our Diethyl 2-(2,4,5-Trifluoro-3-Methoxybenzoyl)Malonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for advanced synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support cGMP compliance for pharmaceutical applications and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.