Description

4-Amino-2,3-difluorobenzonitrile is a high-purity, multi-functional aromatic intermediate featuring both amino and nitrile groups on a difluorinated benzene ring. This unique molecular structure makes it a critical building block for synthesizing complex, value-added compounds, particularly in advanced material science and life sciences. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require a reliable and consistent source of this fluorinated aniline derivative to drive innovation in their R&D and production processes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders, oncology, and anti-infectives, where the fluorine atoms can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoro and nitrile groups contribute to improved pesticidal activity and environmental profile.
• Liquid Crystal & OLED Material: Serves as a core structure for creating advanced electronic materials, including liquid crystal display (LCD) components and organic light-emitting diode (OLED) host or transport materials.
• Polymer & Resin Modifier: Incorporated into polymer chains to impart specific properties such as chemical resistance, thermal stability, or unique optical characteristics in high-performance engineering plastics.
• Dye & Pigment Intermediate: Utilized in the production of specialized dyes and pigments, where the amino and cyano groups allow for the creation of vibrant and stable colorants.
• Cross-coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) for constructing complex biaryl and heteroaryl structures.

Basic Information

Product Name	4-Amino-2,3-difluorobenzonitrile
CAS No.	112279-71-7
Molecular Formula	C7H4F2N2
Molecular Weight	154.12 g/mol
Synonyms	2,3-Difluoro-4-aminobenzonitrile; 4-Amino-2,3-difluorobenzene carbonitrile; 4-Cyano-2,3-difluoroaniline; Benzonitrile, 4-amino-2,3-difluoro-; 2,3-Difluoro-4-cyanobenzenamine
EINECS	Contact for details

Quality Control

Our 4-Amino-2,3-difluorobenzonitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided and available upon request, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.