Description

4-Amino-2,5-Difluorobenzonitrile is a high-purity aromatic nitrile building block featuring both amino and fluorine substituents. This compound matters as a versatile and critical intermediate for synthesizing complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing heterocyclic compounds and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, leveraging the fluorine atoms for enhanced bioactivity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the production of advanced polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for creating specialized dyes, pigments, and optical brighteners due to its amino and cyano functional groups.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Fluorinated Compound Library: Essential for medicinal chemistry programs focused on building fluorinated compound libraries to explore structure-activity relationships (SAR).

Basic Information

Product Name	4-Amino-2,5-Difluorobenzonitrile
CAS No.	112279-61-5
Molecular Formula	C7H4F2N2
Molecular Weight	154.12 g/mol
Synonyms	2,5-Difluoro-4-aminobenzonitrile; 4-Amino-2,5-difluorobenzene carbonitrile; 2,5-Difluoro-4-cyanobenzeneamine; Benzonitrile, 4-amino-2,5-difluoro-; 4-Cyano-2,5-difluoroaniline; 2,5-Difluoro-4-aminophenyl cyanide; 4-Amino-2,5-difluorophenyl cyanide
EINECS	Contact for details

Quality Control

Our 4-Amino-2,5-Difluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.