Description

1-Chloro-5-Fluoro-2-Methyl-4-Nitro-Benzene is a high-purity halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile, multi-functional scaffold for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research chemists and process development scientists in fine chemical, pharmaceutical, and agrochemical industries who require reliable, high-quality intermediates for drug discovery and active ingredient development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing halogenated aromatic systems.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides, where the chloro-fluoro-nitro substitution pattern is biologically active.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex organic dyes and pigments due to its nitro and halogen functional groups.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for creating biaryl structures.
• Nucleophilic Aromatic Substitution: The nitro and halogen groups make it an excellent substrate for nucleophilic displacement reactions to introduce diverse functionalities.

Basic Information

Product Name	1-Chloro-5-Fluoro-2-Methyl-4-Nitro-Benzene
CAS No.	112108-73-3
Molecular Formula	C7H5ClFNO2
Molecular Weight	189.57 g/mol
Synonyms	4-Chloro-2-fluoro-5-methyl-1-nitrobenzene; 2-Fluoro-4-chloro-5-methylnitrobenzene; 5-Chloro-1-fluoro-2-methyl-4-nitrobenzene; 2-Methyl-4-nitro-1-chloro-5-fluorobenzene; Benzene, 1-chloro-5-fluoro-2-methyl-4-nitro-; 1-Chloro-5-fluoro-2-methyl-4-nitrobenzene; 4-Nitro-1-chloro-5-fluoro-2-methylbenzene
EINECS	Contact for details

Quality Control

Our 1-Chloro-5-Fluoro-2-Methyl-4-Nitro-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent composition suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.