Description

18-Hydroxy-19-Norcorticosterone is a specialized steroid derivative of significant interest in biochemical and pharmaceutical research. This compound serves as a key intermediate and reference standard in the study of corticosteroid biosynthesis, metabolism, and receptor interactions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and contract manufacturing organizations (CMOs) engaged in advanced steroid chemistry, endocrine research, and novel therapeutic development.

Application

• Pharmaceutical Research & Development: Critical intermediate in the synthesis and study of novel corticosteroid analogs and potential therapeutic agents.
• Biochemical Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and other chromatographic methods for quantifying related steroids in biological matrices.
• Endocrinology Studies: Employed in in vitro and in vivo research to investigate adrenal cortex function, steroidogenic enzyme activity (e.g., 11β-hydroxylase, 18-hydroxylase), and metabolic pathways.
• Academic Research: A valuable tool in university and institutional labs for fundamental studies on steroid hormone action, receptor binding, and signal transduction mechanisms.
• Process Chemistry: Serves as a building block or precursor in the development and scale-up of synthetic routes for complex steroid molecules within fine chemical and API manufacturing.

Basic Information

Product Name	18-Hydroxy-19-Norcorticosterone
CAS No.	111594-84-4
Molecular Formula	C₂₀H₂₈O₅
Molecular Weight	348.43 g/mol
Synonyms	18-Hydroxy-19-nor-corticosterone; 19-Nor-18-hydroxycorticosterone; 11β,18,21-Trihydroxy-19-norpregn-4-ene-3,20-dione; 18-Hydroxy-19-nor-11-dehydrocorticosterone; 18,21-Dihydroxy-19-norpregn-4-ene-3,11,20-trione (related oxo-form); 19-Nor-18-OH-B
EINECS	Contact for details

Quality Control

Our 18-Hydroxy-19-Norcorticosterone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research-grade specifications. For cGMP or other regulated grade requirements, please contact our technical sales team.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or under refrigeration (2-8°C) for long-term stability, as specified on the label. The container should be kept in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.