Description

13-Methyl-13-Dihydro-4-Demethoxydaunorubicin is a synthetic anthracycline derivative, a key intermediate in the research and development of novel chemotherapeutic agents. Its value lies in its structural relationship to established anticancer drugs like daunorubicin and doxorubicin, allowing for the exploration of modified pharmacological profiles. This compound is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers focused on oncology drug discovery and advanced intermediate synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel anthracycline-based anticancer drugs.
• Oncology Research: Used in biochemical and pharmacological studies to investigate structure-activity relationships (SAR) and mechanisms of action against tumor cells.
• Reference Standard: Employed as a high-purity analytical standard in quality control and method development for related pharmaceutical products.
• Medicinal Chemistry: A valuable scaffold for the design and development of new chemical entities with potential antitumor activity.
• Academic Research: Utilized in university and institutional labs for studies on DNA intercalation, topoisomerase inhibition, and drug resistance mechanisms.

Basic Information

Product Name	13-Methyl-13-Dihydro-4-Demethoxydaunorubicin
CAS No.	111248-05-6
Molecular Formula	C₂₇H₂₉NO₉
Molecular Weight	511.52 g/mol
Synonyms	4-Demethoxy-13-methyl-13-dihydrodaunorubicin; 13-Methyl-13-dihydro-4-demethoxydaunomycin; 13-Methyl-13-dihydrocarminomycin I; 4-Demethoxy-13-methyl-13-dihydrodaunomycin; ID-6105; (8S,10S)-8-Acetyl-10-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-1-methoxy-13-methyl-7,8,9,10-tetrahydrotetracene-5,12-dione
EINECS	Contact for details

Quality Control

Our 13-Methyl-13-Dihydro-4-Demethoxydaunorubicin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere for long-term preservation. Keep the container in a dry, well-ventilated place.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.