Description

1-Bromo-2-Chloro-4-Fluoro-5-Nitrobenzene is a high-purity, multi-substituted aromatic building block essential for advanced organic synthesis. Its unique halogen and nitro substitution pattern makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in the development of fluorinated and halogenated active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the halogen atoms contribute to biological activity and environmental stability.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing nitro and halogen groups.
• Chemical Derivatization: The reactive sites allow for sequential functionalization, making it valuable for creating libraries of compounds in medicinal chemistry and discovery chemistry.
• Dye and Pigment Intermediate: Employed in the synthesis of complex, color-fast dyes and specialty pigments where halogenation is required for specific properties.

Basic Information

Product Name	1-Bromo-2-Chloro-4-Fluoro-5-Nitrobenzene
CAS No.	111010-08-3
Molecular Formula	C6H2BrClFNO2
Molecular Weight	254.44 g/mol
Synonyms	2-Bromo-1-Chloro-4-Fluoro-5-Nitrobenzene; 5-Nitro-1-Bromo-2-Chloro-4-Fluorobenzene; Benzene, 1-bromo-2-chloro-4-fluoro-5-nitro-; 4-Fluoro-5-nitro-1-bromo-2-chlorobenzene; BCFNB (abbreviation); 2-Chloro-4-fluoro-5-nitro-1-bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Chloro-4-Fluoro-5-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.