Description

4-Chloro-3-Fluorobenzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the benzonitrile core, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to introduce specific halogenated aromatic motifs into active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of kinase inhibitors, anti-cancer agents, and other biologically active molecules.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the halogenated aromatic ring contributes to efficacy and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for creating specialized fluorinated and chlorinated components in electronic display and lighting technologies.
• Polymer & Resin Modifier: Incorporated into high-performance polymers to enhance thermal stability, chemical resistance, and specific material properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution reactions to introduce functionalized aryl groups.
• Research & Development: A valuable compound for academic and industrial R&D in medicinal chemistry, material science, and synthetic methodology development.

Basic Information

Item	Detail
Product Name	4-Chloro-3-Fluorobenzonitrile
CAS No.	110888-15-8
Molecular Formula	C7H3ClFN
Molecular Weight	155.56 g/mol
Synonyms	3-Fluoro-4-chlorobenzonitrile; 4-Chloro-3-fluorobenzene carbonitrile; 4-Chloro-3-fluorophenyl cyanide; Benzonitrile, 4-chloro-3-fluoro-; 1-Chloro-2-fluoro-4-cyanobenzene; 2-Fluoro-4-cyanochlorobenzene; 4-Cyano-2-fluorochlorobenzene; 110888-15-8
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	65 - 69 °C
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.