Description

3-Fluoro-5-Nitrobenzonitrile is a high-purity fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its unique structure, featuring both an electron-withdrawing nitro group and a fluorine atom ortho to the nitrile, makes it a critical intermediate for constructing complex molecules with tailored electronic properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atom enhances bioavailability and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials, such as non-linear optical (NLO) chromophores and components for organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Utilized to synthesize fluorinated probes and tags for studying biological mechanisms and enzyme activity.
• Custom Synthesis and Contract Manufacturing: A fundamental building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences sector.

Basic Information

Product Name	3-Fluoro-5-Nitrobenzonitrile
CAS No.	110882-60-5
Molecular Formula	C7H3FN2O2
Molecular Weight	166.11 g/mol
Synonyms	5-Nitro-3-fluorobenzonitrile; 3-Fluoro-5-nitrobenzenecarbonitrile; Benzonitrile, 3-fluoro-5-nitro-; 3-Fluoro-5-nitro-benzonitrile; 2-Fluoro-5-cyanobenzene-1-nitro; 1-Cyano-3-fluoro-5-nitrobenzene; 3-Fluoro-5-nitro phenyl cyanide
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-Nitrobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, open flames, and strong oxidizing agents. The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 99 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.