Description

21-Fluoroprednisone is a synthetic fluorinated corticosteroid derivative, a key intermediate in advanced pharmaceutical synthesis. Its value lies in its role as a crucial building block for developing potent anti-inflammatory and immunosuppressive agents. This compound is essential for research and development laboratories and manufacturers in the pharmaceutical industry, particularly those focused on novel steroid-based therapeutics. The product is supplied as a high-purity material to ensure reliable and consistent results in critical applications.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the production of advanced corticosteroid drugs.
• Research & Development: Utilized in medicinal chemistry for the discovery and optimization of new glucocorticoid receptor agonists.
• Biochemical Research: Serves as a tool compound in studies investigating steroid hormone action, metabolism, and receptor binding.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Process Chemistry: Employed in scale-up and process optimization for the commercial manufacturing of fluorinated steroid APIs.

Basic Information

Product Name	21-Fluoroprednisone
CAS No.	110558-69-5
Molecular Formula	C21H27FO5
Molecular Weight	378.44 g/mol
Synonyms	21-Fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione; 21-Fluoroprednisolone; 9α-Fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione; 21-Fluoro-δ1-cortisol; Fluoroprednisone; 21-Fluoro-17α,21-dihydroxypregna-1,4-diene-3,11,20-trione
EINECS	Contact for details

Quality Control

Our 21-Fluoroprednisone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring full traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.