Description

n-Cholyl-2-Fluoro-β-Alanine is a synthetic bile acid derivative, specifically a fluorinated conjugate of cholic acid and β-alanine. This compound is of significant interest in pharmaceutical research and development due to its potential role as a metabolic probe or a precursor in the synthesis of novel diagnostic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced metabolic studies, liver function diagnostics, and the development of targeted therapeutic conjugates.

Application

• Pharmaceutical Research: Serves as a key intermediate or reference standard in the development of novel hepatobiliary agents and metabolic modulators.
• Diagnostic Agent Synthesis: Used as a precursor for radiolabeled compounds (e.g., with Fluorine-18) for Positron Emission Tomography (PET) imaging of liver and intestinal function.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies related to bile acid metabolism and transport proteins.
• Prodrug Development: Investigated for its utility in designing targeted prodrugs that exploit bile acid transporters for enhanced drug delivery.
• Reference Material: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Detail
Product Name	n-Cholyl-2-Fluoro-β-Alanine
CAS No.	110501-27-4
Molecular Formula	C₂₇H₄₄FNO₆
Molecular Weight	497.64 g/mol
Synonyms	2-Fluoro-N-(3α,7α,12α-trihydroxy-5β-cholan-24-oyl)-β-alanine; Fluorocholyltaurine analog; 3α,7α,12α-Trihydroxy-5β-cholan-24-oic Acid 2-Fluoro-β-alaninate; N-[(3α,5β,7α,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl]-2-fluoro-β-alanine; 2-Fluoro-3-[(3α,7α,12α-trihydroxy-5β-cholan-24-yl)amino]propanoic Acid
EINECS	Contact for details

Quality Control

Our n-Cholyl-2-Fluoro-β-Alanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and determination of residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.