Description

11β-Hydroxy-16α-Methyl-17,20:20,21-Bis(Methylenedioxy)-Pregn-1,4-Dien-3-One CAS NO 110428-42-7 is a high-purity synthetic steroid intermediate of significant importance in advanced pharmaceutical research and development. This compound serves as a critical precursor in the synthesis of potent glucocorticoid receptor modulators and other specialized therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers focused on producing novel corticosteroid derivatives.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel glucocorticoid and anti-inflammatory drug candidates.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic entities.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of steroid-based APIs.
• Biochemical Research: Utilized in studies investigating steroid hormone receptor interactions and signaling pathways.

Basic Information

Product Name	11β-Hydroxy-16α-Methyl-17,20:20,21-Bis(Methylenedioxy)-Pregn-1,4-Dien-3-One
CAS No.	110428-42-7
Molecular Formula	C₂₅H₃₂O₆
Molecular Weight	428.52 g/mol
Synonyms	11β-Hydroxy-16α-methyl-17,20:20,21-bis(methylenedioxy)pregna-1,4-dien-3-one; 16α-Methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione cyclic 17,20:20,21-bis(methyl acetal); Prednisolone 17,20:20,21-bis(methylenedioxy)-16α-methyl derivative; 11β-Hydroxy-16α-methylprednisolone 17,20:20,21-bis(methylenedioxy); (11β,16α)-11,17,21-Trihydroxy-16-methylpregna-1,4-diene-3,20-dione cyclic 17,20:20,21-bis(methyl acetal)
EINECS	Contact for details

Quality Control

Our 11β-Hydroxy-16α-Methyl-17,20:20,21-Bis(Methylenedioxy)-Pregn-1,4-Dien-3-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets exacting standards for research and pharmaceutical use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.