Description

13-Methyl-13-Dihydrodaunorubicin is a synthetic derivative of the anthracycline antibiotic daunorubicin, representing a key intermediate in the development of novel chemotherapeutic agents. This compound is of significant interest in pharmaceutical research for its potential to modulate biological activity and improve therapeutic profiles. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery and the synthesis of advanced pharmaceutical intermediates.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel anthracycline-based anticancer drugs and prodrugs.
• Oncology Research: Used as a reference standard or active compound in biochemical and pharmacological studies targeting DNA intercalation and topoisomerase II inhibition.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemistry programs aiming to understand and enhance the efficacy and reduce the cardiotoxicity of anthracycline derivatives.
• Academic Research: Employed in university and institutional labs for investigating cancer cell apoptosis mechanisms and drug resistance.
• Bioconjugation Studies: Serves as a candidate for developing antibody-drug conjugates (ADCs) or other targeted delivery systems in cancer therapy.

Basic Information

Product Name	13-Methyl-13-Dihydrodaunorubicin
CAS No.	110403-82-2
Molecular Formula	C₂₈H₃₁NO₁₀
Molecular Weight	541.55 g/mol
Synonyms	13-Methyldaunorubicin; 13-Methyl-13-dihydrodaunomycin; 13-Methyl-13-dihydrodaunorubicin hydrochloride (salt form); 13-Methyl-13-dihydro-7,8,9,10-tetrahydro-6,11-dihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; 13-Methyl-13-dihydrodaunorubicinol (related metabolite); Daunorubicin, 13-methyl-13-dihydro-; 13-Methyl-DNR
EINECS	Contact for details

Quality Control

Our 13-Methyl-13-Dihydrodaunorubicin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of related substances and residual solvents. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. The container should be kept in a dry, well-ventilated area, and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Red to orange-red powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Single Unknown Impurity	≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.