Description

Adozelesin is a potent synthetic derivative of the natural antitumor antibiotic CC-1065, belonging to the cyclopropylpyrroloindole (CPI) class of DNA alkylating agents. This compound is of significant interest in advanced pharmaceutical research due to its sequence-selective DNA binding and potent cytotoxic activity. It is primarily utilized by research institutions and pharmaceutical developers focused on oncology, serving as a critical tool for investigating novel cancer therapeutics and understanding DNA-interactive drug mechanisms.

Application

• Oncology Research: Serves as a key reference standard and active pharmaceutical ingredient (API) in preclinical studies for novel anticancer drug development.
• Mechanistic Studies: Used to investigate the biochemical pathways of DNA minor groove alkylation and subsequent cellular apoptosis.
• Pharmaceutical Intermediates: Acts as a sophisticated building block for the synthesis of next-generation targeted therapies and antibody-drug conjugates (ADCs).
• Biochemical Reagent: Employed in assays to study DNA damage response and repair mechanisms within cellular systems.
• Standards and Controls: Provides a high-purity standard for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	Adozelesin
CAS No.	110314-48-2
Molecular Formula	C31H35N3O6
Molecular Weight	545.63 g/mol
Synonyms	U-73975; Adozelesin (U-73975); (+)-CC-1065-(N3-Adenine); 1,2,8,8a-Tetrahydro-7-methyl-8a-[[(phenylmethoxy)carbonyl]amino]cycloprop[g]pyrrolo[3,2-e]indol-4(5H)-one, (1aS,8aS)-rel-; U 73975; NSC 606174; (+)-Adozelesin
EINECS	Contact for details

Quality Control

Our Adozelesin is manufactured under strict quality management systems to ensure the highest standards of purity and consistency for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for research-grade chemicals, ensuring reliable and reproducible performance in your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.