Description

Amrubicin CAS NO 110267-81-7 is a synthetic anthracycline derivative and a potent topoisomerase II inhibitor. This compound is of critical importance as an active pharmaceutical ingredient (API) in the development and manufacture of chemotherapeutic agents. It is primarily required by pharmaceutical manufacturers and research institutions focused on oncology, specifically for the treatment of small cell lung cancer and other malignancies.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of injectable chemotherapeutic drugs.
• Oncology Research: A key reference standard and investigational compound in cancer biology and mechanism of action studies.
• Drug Development: Used in preclinical and clinical trials for developing new anti-cancer therapies and combination regimens.
• Biochemical Research: Employed as a tool compound to study DNA intercalation, topoisomerase II inhibition, and apoptosis pathways.
• Pharmaceutical Intermediates: Serves as a critical intermediate in the synthesis of more complex anthracycline-based drug candidates.

Basic Information

Product Name	Amrubicin
CAS No.	110267-81-7
Molecular Formula	C₂₅H₂₅NO₉
Molecular Weight	483.47 g/mol
Synonyms	Amrubicin Hydrochloride; SM-5887; (7S,9S)-9-Acetyl-9-amino-7-[(2-deoxy-β-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione; Calsed; 7-Deoxy-9,10-didehydro-13-dihydrodaunorubicin; Amrubicin HCl
EINECS	Contact for details

Quality Control

Our Amrubicin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided, confirming identity, purity, and impurity profiles as per in-house specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Orange to red-orange powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.