Description

4-[(S)-3-[(1,1-Dimethylethyl)Amino]-2-Hydroxypropoxy]Benzeneethanol is a high-purity chiral intermediate of significant importance in the synthesis of active pharmaceutical ingredients (APIs). Its value lies in its specific stereochemistry and functional groups, which are critical for producing enantiomerically pure compounds with targeted biological activity. This product is essential for pharmaceutical R&D and manufacturing, particularly for companies developing β-adrenergic blocking agents and other cardiovascular or ophthalmic therapeutics.

Application

• Key Intermediate in β-Blocker Synthesis: Primarily used in the production of S-enantiomer β-adrenergic antagonists (β-blockers) like S-Timolol.
• Pharmaceutical Research & Development: Serves as a critical building block for medicinal chemists exploring new chiral drug candidates.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the commercial-scale synthesis of ophthalmic solutions and cardiovascular drugs.
• Chiral Auxiliary and Resolving Agent: Can be utilized in asymmetric synthesis and the separation of enantiomers.
• Reference Standard: Used as a high-purity standard in analytical laboratories for quality control and method development.

Basic Information

Product Name	4-[(S)-3-[(1,1-Dimethylethyl)Amino]-2-Hydroxypropoxy]Benzeneethanol
CAS No.	109833-45-6
Molecular Formula	C15H25NO3
Molecular Weight	267.36 g/mol
Synonyms	(S)-4-[3-(tert-Butylamino)-2-hydroxypropoxy]phenethyl alcohol; (S)-Timolol Intermediate; (S)-1-(tert-Butylamino)-3-[(4-(2-hydroxyethyl)phenoxy]-2-propanol; S-(-)-4-[3-(tert-Butylamino)-2-hydroxypropoxy]benzeneehtanol; Levobunolol Related Compound; S-Timolol Alcohol; (S)-Phenylethanolamine Derivative
EINECS	Contact for details

Quality Control

Our 4-[(S)-3-[(1,1-Dimethylethyl)Amino]-2-Hydroxypropoxy]Benzeneethanol is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical development, supported by comprehensive analytical testing. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles are available for every batch. Our quality commitment ensures compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S-enantiomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.