Description

4(O)-Daunosaminyl-2,4,5,12-Tetrahydroxy-2-Pentanoyl-1,2,3,4-Tetrahydro-6,11-Naphthacenedione is a complex semisynthetic anthracycline derivative of significant interest in advanced pharmaceutical research and development. This compound is valued for its potential as a key intermediate or active moiety in the synthesis of novel chemotherapeutic agents, offering a foundation for creating targeted cancer therapies. It is primarily required by pharmaceutical R&D laboratories, biotechnology firms, and academic institutions focused on oncology drug discovery and the development of next-generation antitumor antibiotics.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel anthracycline-based anticancer drugs.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of action, structure-activity relationships (SAR), and drug resistance.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).
• Preclinical Development: Utilized in in vitro and in vivo studies to evaluate the efficacy and toxicity profiles of new drug candidates.
• Academic Research: Supports fundamental chemical and biological research into DNA intercalation and topoisomerase II inhibition.
• Process Chemistry: Acts as a starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	4(O)-Daunosaminyl-2,4,5,12-Tetrahydroxy-2-Pentanoyl-1,2,3,4-Tetrahydro-6,11-Naphthacenedione
CAS No.	109485-64-5
Molecular Formula	C32H37NO12
Molecular Weight	627.64 g/mol
Synonyms	4'-O-Daunosaminyl-2,4,5,12-tetrahydroxy-2-pentanoyl-1,2,3,4-tetrahydro-6,11-naphthacenedione; 4'-O-Daunosaminyl-2-pentanoyl-2,4,5,12-tetrahydroxy-1,2,3,4-tetrahydro-6,11-naphthacenedione; 4'-O-Daunosaminyl-2-pentanoyl-2,4,5,12-tetrahydroxy-1,2,3,4-tetrahydroanthra[2,3-b]oxecine-6,11-dione; Daunorubicin 4'-O-pentanoyl derivative; 4'-O-Pentanoyldaunorubicin; 4'-O-Valeryldaunorubicin; 4'-O-(1-Oxopentyl)daunorubicin; 4'-O-Daunosaminyl-2-pentanoyl-tetrahydroanthraquinone derivative
EINECS	Contact for details

Quality Control

Our 4(O)-Daunosaminyl-2,4,5,12-Tetrahydroxy-2-Pentanoyl-1,2,3,4-Tetrahydro-6,11-Naphthacenedione is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific pharmacopeial or internal standards (e.g., >98% HPLC purity) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. Due to its hygroscopic nature, the container should be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH limits
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.