Description

4 o-Daunosaminyl-2,4,5,12-Tetrahydroxy-2-Nonanoyl-1,2,3,4-Tetrahydro-6,11-Naphthacenedione is a structurally complex anthracycline derivative, a class of compounds renowned for their potent biological activity. This compound matters for its role as a key synthetic intermediate or reference standard in advanced pharmaceutical research and development. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and synthesis of novel chemotherapeutic agents, particularly those exploring modifications to anthracycline scaffolds to improve efficacy or reduce side effects.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthetic pathway for novel anthracycline-based anticancer drugs.
• Biochemical Research: Used as a reference standard or probe in studies investigating the structure-activity relationships (SAR) of daunorubicin and doxorubicin analogs.
• Antitumor Agent Development: Acts as a precursor for the development of new chemotherapeutic agents targeting DNA intercalation and topoisomerase II inhibition.
• Academic Research: Employed in university and institutional labs for fundamental research on anthracycline biosynthesis, metabolism, and resistance mechanisms.
• Process Chemistry: Utilized in scaling up and optimizing synthetic routes for complex natural product derivatives under Good Manufacturing Practice (GMP) conditions.
• Quality Control Standard: Functions as a high-purity analytical standard for the identification and quantification of related substances in drug substance batches.

Basic Information

Product Name	4 o-Daunosaminyl-2,4,5,12-Tetrahydroxy-2-Nonanoyl-1,2,3,4-Tetrahydro-6,11-Naphthacenedione
CAS No.	109485-63-4
Molecular Formula	C₃₆H₄₅NO₁₂
Molecular Weight	671.75 g/mol
Synonyms	2-Nonanoyldaunorubicin; 2'-O-Nonanoyldaunorubicin; 4-O-Daunosaminyl-2,4,5,12-tetrahydroxy-2-nonanoyl-1,2,3,4-tetrahydro-6,11-naphthacenedione; 2'-N-Daunorubicin; Daunorubicin 2'-nonanoate; 2'-O-Nonanoyl-13-dihydrodaunorubicin; 2'-N-Daunomycin; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 4 o-Daunosaminyl-2,4,5,12-Tetrahydroxy-2-Nonanoyl-1,2,3,4-Tetrahydro-6,11-Naphthacenedione is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.