Description

14-n-Succinimidocarminomycin is a chemically modified derivative of the anthracycline antibiotic carminomycin, designed for enhanced biological activity and targeted delivery. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its potential as a key intermediate or active component in novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of next-generation oncology treatments and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel anthracycline-based chemotherapeutic agents.
• Anticancer Research: Used in biochemical and pharmacological studies to investigate mechanisms of action against various cancer cell lines.
• Drug Conjugate Development: The succinimido moiety enables conjugation to antibodies, peptides, or polymers for creating targeted drug delivery systems (e.g., Antibody-Drug Conjugates - ADCs).
• Mechanistic Studies: Employed to study DNA intercalation, topoisomerase II inhibition, and the generation of reactive oxygen species (ROS) associated with anthracycline activity.
• Structure-Activity Relationship (SAR) Analysis: A key compound for modifying the carminomycin scaffold to improve efficacy and reduce cardiotoxicity.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	14-n-Succinimidocarminomycin
CAS No.	108936-90-9
Molecular Formula	C30H31N3O12
Molecular Weight	625.58 g/mol
Synonyms	14-n-Succinimidocarminomycin; 14-N-Succinimidocarminomycin; Carminomycin 14-N-succinimide; 14-N-Succinimido-carminomycin; 14-Succinimidocarminomycin; N-Succinimidyl carminomycin-14-carbamate; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione 14-[N-(2,5-dioxo-1-pyrrolidinyl)]carbamate
EINECS	Contact for details

Quality Control

Our 14-n-Succinimidocarminomycin is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines to support our clients in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	Red to orange-red powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.