Description

Nemorubicin CAS NO 108852-90-0 is a potent anthracycline derivative and a key pharmaceutical intermediate in oncology research and development. This compound is valued for its role as a precursor in the synthesis of advanced chemotherapeutic agents, offering a critical building block for targeted cancer therapies. It is primarily utilized by pharmaceutical manufacturers, research institutions, and biotechnology companies engaged in the development of novel anti-cancer drugs and drug delivery systems.

Application

• Pharmaceutical Intermediate: A crucial starting material or intermediate in the synthesis of nemorubicin hydrochloride and other anthracycline-based chemotherapeutic agents.
• Oncology Research: Used in biochemical and pharmacological research to study the mechanisms of action of anthracycline drugs, including DNA intercalation and topoisomerase II inhibition.
• Drug Discovery & Development: Serves as a reference standard and a key scaffold in medicinal chemistry programs aimed at developing new anticancer compounds with improved efficacy and reduced cardiotoxicity.
• Preclinical Studies: Employed in in vitro and in vivo studies to evaluate antitumor activity, pharmacokinetics, and toxicology profiles.
• Analytical Reference Standard: Used in quality control laboratories for the identification and quantification of nemorubicin in active pharmaceutical ingredients (APIs) and finished drug products via HPLC, LC-MS, or other analytical methods.

Basic Information

Item	Details
Product Name	Nemorubicin
CAS No.	108852-90-0
Molecular Formula	C₃₂H₃₅NO₁₂
Molecular Weight	625.62 g/mol
Synonyms	3'-Deamino-3'-[2-(S)-methoxy-4-morpholinyl]doxorubicin; PNU-152243; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; 3'-Deamino-3'-(2-methoxy-4-morpholinyl)doxorubicin; Nemorubicin base
EINECS	Contact for details

Quality Control

Our Nemorubicin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with a detailed Certificate of Analysis (COA), which includes data from advanced techniques such as HPLC for assay and related substances, IR for identification, and residual solvent analysis. Specifications are designed to meet the stringent requirements of pharmaceutical R&D and GMP-grade production.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). It is recommended to store under an inert gas (e.g., nitrogen or argon) in a desiccated environment to maintain purity and prevent degradation. Keep the container securely sealed when not in use.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.